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​Publications

For a complete list of publications, please visit Prof. Wangikar’s Google Scholar profile.​​

​

 

2025

 

  • Metabolic engineering and metabolomics based profiling of cyanobacteria for enhanced succinate production

 

Srivastava M..; Wangikar, P.P. ​

Algal research, 91:104286. https://doi.org/10.1016/j.algal.2025.104286

 

  • Untargeted exometabolic profiling unveils natural product repertoire of the fast-growing cyanobacterium Synechococcus elongatus PCC 11801

 

Jain V.S.; Bingi G.B.; Ganjave S.D.; Pandey R.; Sunder A.; Wangikar, P.P. ​

Process Biochemistry, 157:300-307. https://doi.org/10.1016/j.procbio.2025.08.002

 

  • Whole blood metabolome profiling for stratification of type 2 diabetes patients and identification of biomarkers for diabetic kidney disease in Asian Indian adults

 

Rana S.; Mishra V.; Nakrani P.; Ega L.K.; Sahay M.; Sahay R.K.; Wangikar P.P. ​

ACS Proteome Research, 24(8):4114-4125. https://doi.org/10.1021/acs.jproteome.5c00188

 

  • Metabolomic profiling reveals grade-specific niacinamide accumulation and its therapeutic potential via SIRT1-CD38-EMT axis modulation in cervical cancer progression

Jaiswal S.; Mishra V.; Majumder S.; Wangikar P.P.; Senguta S. ​

Biochimica et Biophysica Acta - Molecular Cell Research, 1872: 119994. https://doi.org/10.1016/j.bbamcr.2025.119994

 

  • ​Dures: An R package for denoising experimental tandem mass spectra and metabolite annotation

 

Banerjee S.; Nakrani P.; Singh A.; Wangikar P.P

ACS Analytical Chemistry, 97(23):11986-11992. https://doi.org/10.1021/acs.analchem.5c01726

 

  • Process intensification for recombinant protein production in E. coli via identification of active nodes in cellular metabolism and dynamic flux balance analysis

 

Dodia H.; Muddana C.; Mishra V.; Sunder A.V.; Wangikar P.P.

Biotechnology and Bioengineering, 122:2037-2048. https://doi.org/10.1002/bit.29012​

 

  • Engineering Synechococcus elongatus IITB6 as a highly efficient ethanol bioproduction host

 

Jain V.J.; Sahasrabuddhe D.; Sunder A.V.; Wangikar P.P.

Biochemical Engineering Journal, 215:109638, https://doi.org/10.1016/j.bej.2025.109638

 
 

  • Metabolic engineering of rapidly growing Synechococcus elongatus strains for phototrophic production of alkanes

 

Srivastava V.; Sarnaik A.P.; Wangikar P.P.

Biotechnology Progress, 14:e3509, https://doi.org/10.1002/btpr.3509

2024

 

  • Metabolic engineering of fast growing cyanobacteria for phototrophic production of 2,3-butanediol

 

Srivastava V.; Wangikar P.P.

Biochemical Engineering Journal, 210:109439, https://doi.org/10.1016/j.bej.2024.109439

 
 
 

  • Expanding the synthetic biology repertoire of a fast-growing cyanobacterium Synechococcus elongatus PCC 11801

Madhu S.; Sengupta A.; Sarnaik A.P.; Wangikar P.P.

Biotechnology and Bioengineering, 121:2974-2980, https://doi.org/10.1002/bit.28740​

 

  • Intracellular metabolomic profiling of Picochlorum sp. under diurnal conditions mimicking outdoor light, temperature, and seasonal variations

 

Pritam P.; Manjre S.; Shukla M.R.; Srivastava M.; Prasannan C.B.; Jaiswal D.; Davis.; Dasgupta S.; Wangikar P.P.

Metabolomics, 20:107, https://doi.org/10.1007/s11306-024-02170-7​

 
 
 

  • Dynamic flux balance analysis of high cell density fed-batch culture of Escherichia coli BL21 (DE3) with mass spectrometry-based spent media analysis

 

Dodia H.; Mishra V..; Nakrani P.; Muddana C.; Kedia A.; Rana S., Sahasrabuddhe D.; Wangikar P.P.

Biotechnology and Bioengineering, 121:1393-1405. https://doi.org/10.1002/bit.28654​

 
 

  • De novo genome assembly and pan-genome analysis of the fast-growing Indian isolates of Synechococcus elongatus: Potential chassis for bioproduction

 

Jain V.; Schubert M.G.; Sarnaik A.P; Pritam P.; Jaiswal D.; Church G.M.; Wangikar P.P.

The Microbe, 2:100048, https://doi.org/10.1016/j.microb.2024.100048​

 
 

2023

 

  • Global transcriptome-guided identification of neutral sites for engineering Synechococcus elongatus PCC 11801

 

Madhu S.; Sengupta A.; Sarnaik A.P.; Sahasrabuddhe D.; Wangikar P.P.

ACS Synthetic Biology, 12:1677-1685, https://doi.org/10.1021/acssynbio.3c00019

 
 

  • Precision fermentation with mass spectrometry-based spent media analysis

 
 

Dodia H.; Sunder A.V.; Borkar Y.; Wangikar P.P.

Biotechnology and Bioengineering, 120:2809-2826, https://doi.org/10.1002/bit.28450​​

 

  • Rate of dilution and redox ratio influence the refolding efficiency of recombinant fungal dehydrogenases

 
 

Ganjave S.D.; O'Niel R.A.; Wangikar P.P.

International Journal of Biological Macromolecules, 250:126163. https://doi.org/10.1016/j.ijbiomac.2023.126163​

 

  • Metabolic engineering of Synechococcus elongatus for photoautotrophic production of mannitol

 

​Pritam P.; Sarnaik A.P.; Wangikar P.P.

Biotechnology and Bioengineering, 120:2363-2370. https://doi.org/10.1002/bit.28479​

 

  • Isotopically non-stationary 13C metabolic flux analysis of two closely related fast-growing cyanobacteria, Synechococcus elongatus PCC 11801 and 11802

 

Jaiswal D.; Nenwani M.; Wangikar P.P.

Plant Journal, 116, 558-573. https://doi.org/10.1111/tpj.16316​

​

2022

 

  • Probing the metabolism of γ-glutamyl peptides in cyanobacteria via metabolite profiling and 13C labeling

 

Jaiswal D.; Nenwani M.; Mishra V.; Wangikar P.P.

Plant Journal, 109, 708-726. https://doi.org/10.1111/tpj.15564

  • Transporter engineering for the development of cyanobacteria as cell factories: A text analytics guided survey

 
 

Sengupta S.; Sahasrabuddhe D.; Wangikar P.P.

Biotechnology Advances, 54:107816. https://doi.org/10.1016/j.biotechadv.2021.107816​​

 

  • Transmembrane shuttling of photosynthetically produced electrons to propel extracellular biocatalytic redox reactions in a modular fashion

 
 

Jurkaš V.; Weissensteiner F.; De Santis P.; Vrabl S.; Sorgenfrei F.A.; Bierbaumer S.; Kara S.; Kourist R.; Wangikar P.P.; Winkler C.K.; Kroutil W.

Angewandte Chemie - International Edition, 61:e202207971. https://doi.org/10.1002/anie.202207971​​

​

  • High cell density cultivation of E. coli in shake flasks for the production of recombinant proteins

 

Ganjave S.D.; Dodia H.; Sunder A.V.; Madhu S.; Wangikar P.P.

Biotechnology Reports, 33:e00694. https://doi.org/10.1016/j.btre.2021.e00694​​​

  • Cyanobacteria as cell factories: the roles of host and pathway engineering and translational research

 

Jaiswal D.; Sahasrabuddhe D.; Wangikar P.P.

Current Opinion in Biotechnology, 73:314-322. https://doi.org/10.1016/j.copbio.2021.09.010​​​

2021

 

  • Traits of fast-growing cyanobacteria

 

Srivastava M.; Hudson E.P.; Wangikar P.P.

Cyanobacteria Biotechnology (Book Chapter). https://doi.org/10.1002/9783527824908.ch14

 

  • Adaptive laboratory evolution of the fast-growing cyanobacterium Synechococcus elongatus PCC 11801 for improved solvent tolerance

 
 
 

Srivastava V.; Amanna R.; Rowden S.J.L.; Sengupta S.; Madhu S.; Howe C.J.; Wangikar P.P.

Journal of Bioscience and Bioengineering, 131:491-500. https://doi.org/10.1016/j.jbiosc.2020.11.012​​​

  • Cyanobacteria as a renewable resource for biofuel production

 

Sahasrabuddhe D.; Sengupta A.; Sengupta S.; Mishra V.; Wangikar P.P.

Advanced Biofuel Technologies: Present Status, Challenges and Future Prospects (Book Chapter). https://doi.org/10.1016/B978-0-323-88427-3.00006-4​​​

  • Editorial: Bioconversion and biorefinery of C1 compounds

 

​Lee E.Y.; Li F.-L.; Wang Y.; Wangikar P.P.; Guarnieri M.T.; Luan G.

Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2021.778962​​​

2020

 

  • Expanding the repertoire of nitrilases with broad substrate specificity and high substrate tolerance for biocatalytic applications

 

Sunder A.V.; Shah S.; Rayavarapu P.; Wangikar P.P.

Process Biochemistry, 94:289-296. https://doi.org/10.1016/j.procbio.2020.05.004

  • Photosynthetic co-production of succinate and ethylene in a fast-growing cyanobacterium, Synechococcus elongatus PCC 11801

​

Sengupta A.; Pritam P.; Jaiswal D.; Bandyopadhyay A.; Pakrasi H.B.; Wangikar P.P.

Metabolites. 10:250. https://doi.org/10.3390/metabo10060250​​​

 

  • Effect of elevated carbon dioxide and nitric oxide on the physiological responses of two green algae, Asterarcys quadricellulare and Chlorella sorokiniana

Varshney P.; Beardall J.; Bhattacharya S.; Wangikar P.P.

Journal of Applied Phycology, 32:189-204. https://doi.org/10.1007/s10811-019-01950-2​​​

  • Metabolic engineering of cyanobacteria for production of platform chemicals: A synthetic biology approach

Arora N.; Jaiswal D.; Sengupta S.; Wangikar P.P.

Handbook of Algal Science, Technology and Medicine (Book Chapter). https://doi.org/10.1016/B978-0-12-818305-2.00008-5​​​

 

  • The role of systems biology in developing non-model cyanobacteria as hosts for chemical production

Mukherjee B.; Madhu S.; Wangikar P.P.

Current Opinion in Biotechnology, 64:62-69. https://doi.org/10.1016/j.copbio.2019.10.003​​​

 

  • A Novel Cyanobacterium Synechococcus elongatus PCC 11802 has Distinct Genomic and Metabolomic Characteristics Compared to its Neighbor PCC 11801

 

Jaiswal D.; Sengupta A.; Sengupta S.; Madhu S.; Pakrasi H.B.; Wangikar P.P.

Current Opinion in Biotechnology, 64, 10:191. https://doi.org/10.1038/s41598-019-57051-0​​​

 

  • Evaluation of freely available software tools for untargeted quantification of 13C isotopic enrichment in cellular metabolome from HR-LC/MS data

Dange M.C.; Mishra V.; Mukherjee B.; Jaiswal D.; Merchant M.S.; Prasannan C.B.; Wangikar P.P.

Metabolic Engineering Communications, 10:e00120. https://doi.org/10.1016/j.mec.2019.e00120​​​

  • Dynamic Inventory of Intermediate Metabolites of Cyanobacteria in a Diurnal Cycle

Jaiswal D.; Wangikar P.P.

iScience, 23:101704. https://doi.org/10.1016/j.isci.2020.101704​​​

 

  • A method to compute instantaneous oxygen evolution rates in cyanobacterial cultures grown in shake flasks

Sengupta A.; Wangikar P.P.

Engineering Reports, 2:e12094. https://doi.org/10.1002/eng2.12094​​​

 
 

  • Characterization and application of a robust glucose dehydrogenase from Paenibacillus pini for cofactor regeneration in biocatalysis

Shah S.; Sunder A.V.; Singh P.; Wangikar P.P.

Indian Journal of Microbiology, 60:87-95. https://doi.org/10.1007/s12088-019-00834-w​​​

  • SWATH: A data-independent tandem mass spectrometry method to quantify 13C enrichment in cellular metabolites and fragments

Jaiswal D.; Wangikar P.P.

Methods in Molecular Biology. https://doi.org/10.1007/978-1-0716-0159-4_9​​​

 

  • A Library of Tunable, Portable, and Inducer-Free Promoters Derived from Cyanobacteria

Sengupta A.; Madhu S.; Wangikar P.P.

ACS Synthetic Biology, 9:1790-1801. https://doi.org/10.1021/acssynbio.0c00152​​​

  • Metabolic engineering of a fast-growing cyanobacterium Synechococcus elongatus PCC 11801 for photoautotrophic production of succinic acid

Sengupta S.; Jaiswal D.; Sengupta A.; Shah S.; Gadagkar S.; Wangikar P.P.

Biotechnology for Biofuels, 13:89. https://doi.org/10.1186/s13068-020-01727-7​​​

 

  • Liquid chromatography methods for separation of polar and charged intracellular metabolites for 13C metabolic flux analysis

Jaiswal D.; Mittal A.; Nagrath D.; Wangikar P.P.

Methods in Molecular Biology. https://doi.org/10.1007/978-1-0716-0159-4_3​​​

 

2019

 

  • Elevated carbon dioxide levels lead to proteome-wide alterations for optimal growth of a fast-growing cyanobacterium, Synechococcus elongatus PCC 11801

 

Mehta K.; Jaiswal D.; Nayak M.; Prasannan C.B.; Wangikar P.P.; Srivastava S.

Scientific Reports, 9:6257. https://doi.org/10.1038/s41598-019-42576-1

 

  • The effect of CO2 in enhancing photosynthetic cofactor recycling for alcohol dehydrogenase mediated chiral synthesis in cyanobacteria

Sengupta A.; Sunder A.V.; Sohoni S.V.; Wangikar P.P.

Journal of Biotechnology, 289.:1-6. https://doi.org/10.1016/j.jbiotec.2018.11.002​​

 
 

  • Mass Isotopologue Distribution of dimer ion adducts of intracellular metabolites for potential applications in 13C Metabolic Flux Analysis

Prasannan C.B.; Mishra V.; Jaiswal D.; Wangikar P.P.

PLoS ONE, 14:e0220412. https://doi.org/10.1371/journal.pone.0220412​​​

  • Fine-tuning native promoters of Synechococcus elongatus PCC 7942 to develop a synthetic toolbox for heterologous protein expression

Sengupta A.; Sunder A.V.; Sohoni S.V.; Wangikar P.P.

ACS Synthetic Biology, 8:1219-1223. https://doi.org/10.1021/acssynbio.9b00066​​​

 

2018

 

  • An improved method for extraction of polar and charged metabolites from cyanobacteria

 

Prasannan C.B.; Jaiswal D.; Davis R.; Wangikar P.P.

PLoS ONE, 13:e0204273. https://doi.org/10.1371/journal.pone.0204273

  • CFD analysis of the flow dynamics of microorganisms in dilute cultures in stirred tank photobioreactors

Saini R.K.; Wangikar P.P.; Bose M.

Bioresource Technology Reports, 3:238-246. https://doi.org/10.1016/j.biteb.2018.07.017​​​

  • SWATH tandem mass spectrometry workflow for quantification of mass isotopologue distribution of intracellular metabolites and fragments labeled with isotopic 13C carbon

Jaiswal D.; Prasannan C.B.; Hendry J.I.; Wangikar P.P.

Analytical Chemistry, 90:6486-6493. https://doi.org/10.1021/acs.analchem.7b05329​​​

 

  • Development of biotransformation process for asymmetric reduction with novel anti-Prelog NADH-dependent alcohol dehydrogenases

Shah S.; Agera R.; Sharma P.; Sunder A.V.; Bajwa H.; James H.M.; Gaikaiwari R.P.; Wangikar P.P.

Process Biochemistry, 70:71-78. https://doi.org/10.1016/j.procbio.2018.04.016​​​

  • Genome features and biochemical characteristics of a robust, fast growing and naturally transformable cyanobacterium Synechococcus elongatus PCC 11801 isolated from India

Jaiswal D.; Sengupta A.; Sohoni S.; Sengupta S.; Phadnavis A.G.; Pakrasi H.B.; Wangikar P.P.

Scientific Reports, 8:16632. https://doi.org/10.1038/s41598-018-34872-z​​​

  • Cyanobacteria: Promising biocatalysts for sustainable chemical production

Knoot C.J.; Ungerer J.; Wangikar P.P.; Pakrasi H.B..

Journal of Biological Chemistry, 293:5044-5052. https://doi.org/10.1074/jbc.R117.815886​​​

  • Recent advances in synthetic biology of cyanobacteria

Sengupta A.; Pakrasi H.B.; Wangikar P.P.

Applied Microbiology and Biotechnology, 102:5457-5471. https://doi.org/10.1007/s00253-018-9046-x​​​

 

  • Isolation and biochemical characterisation of two thermophilic green algal species- Asterarcys quadricellulare and Chlorella sorokiniana, which are tolerant to high levels of carbon dioxide and nitric oxide

Varshney P.; Beardall J.; Bhattacharya S.; Wangikar P.P.

Algal Research, 30:28-37. https://doi.org/10.1016/j.algal.2017.12.006​​​

2017

 

  • Gene essentiality, conservation index and coevolution of genes in cyanobacteria

 

Tiruveedula G.S.S.; Wangikar P.P.

PLoS ONE, 12:e0178565. https://doi.org/10.1371/journal.pone.0178565

 

  • Rerouting of carbon flux in a glycogen mutant of cyanobacteria assessed via isotopically non-stationary 13C metabolic flux analysis

Hendry J.I.; Prasannan C.; Ma F.; Möllers K.B.; Jaiswal D.; Digmurti M.; Allen D.K.; Frigaard N.-U.; Dasgupta S.; Wangikar P.P.

Biotechnology and Bioengineering, 114:2298-2308. https://doi.org/10.1002/bit.26350​​​

 

  • Effect of high CO2 concentrations on the growth and macromolecular composition of a heat- and high-light-tolerant microalga

Varshney P.; Sohoni S.; Wangikar P.P.; Beardall J.

Journal of Applied Phycology, 28:2631-2640. https://doi.org/10.1007/s10811-016-0797-4​​​

  • Multi-omics Frontiers in Algal Research: Techniques and Progress to Explore Biofuels in the Postgenomics World

Rai V.; Karthikaichamy A.; Das D.; Noronha S.; Wangikar P.P.; Srivastava S.

OMICS A Journal of Integrative Biology, 20:387-399. https://doi.org/10.1089/omi.2016.0065​​​

 

  • Metabolic model of Synechococcus sp. PCC 7002: Prediction of flux distribution and network modification for enhanced biofuel production

Hendry J.I.; Prasannan C.B.; Joshi A.; Dasgupta S.; Wangikar P.P.

Bioresource Technology, 213:190-197. https://doi.org/10.1016/j.biortech.2016.02.128​​​

  • Rhythmic oscillations in KaiC1 phosphorylation and ATP/ADP ratio in nitrogen-fixing cyanobacterium Cyanothece sp. ATCC 51142

 

Alagesan S.; Gaudana S.B.; Wangikar P.P.

Biological Rhythm Research, 47:285-301. https://doi.org/10.1080/09291016.2015.1116737​​​

 

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